Hexapeptide

Abstract

NEW MATERIAL:A compound shown by the formula I . USE: An analgesic. PREPARATION: For example, a compound shown by the formula H-Arg(NO 2 )- OBzl.2TosOH (Bzl is benzyl; Tos is paratoluenesulfonyl) is dissolved in DMF, reacted with a compound shown by the formula Z(OMe)-Tyr(Bzl)-OTGCP(Me is methyl; TCP is 2,4,5-trichlorophenyl) in the presence of a tertiary amine to give a compound shown by the formula II. This compound is then reacted with trifluoroacetic acid, and reacted with a compound shown by the formula Boc- Arg(NO 2 )-OH(Boc is t-butyloxycarbonyl) to give a compound shown by the formula III. This compound is further reacted with a compound shown by the formula Z(OMe)-Tyr(Bzl)-OTCP, treated with TFA, and reacted with Boc-Arg (NO 2 )-OH, ethylchoroformate, etc., to give a compound shown by the formula IV. Finally this compound is reacted with a compound shown by the formula Z (OMe)-Tyr(Bzl)-OTCP, and the protecting group is removed, to give a compound shown by the formula I . COPYRIGHT: (C)1985,JPO&Japio

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (0)

    Publication numberPublication dateAssigneeTitle

NO-Patent Citations (0)

    Title

Cited By (0)

    Publication numberPublication dateAssigneeTitle